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Aaron Levie Alain de Botton Alan Watts Alexis Ohanian Andreas Antonopoulos Andrew DeSantis Andrew Lo Arthur De Vany Aubrey de Grey Balaji Srinivasan Ben Bratton Bill Bryson Bryan Caplan Carl Jung Chamath Palihapitiya Chris Arnade Chris Sacca Daniel Dennett Daniel Kahneman David Linden David Sacks Derek Parfit Derek Sivers Douglas Hofstadter E.O. Wilson Elon Musk Eric Weinstein Ezra Klein Gad Saad George Gilder George Lakoff Ido Portal J.D. Vance James Altucher James Gleick Jason Silva Jeff Bezos Jim Simons Jocko Willink John Hagelin John Nash Josh Waitzkin Julia Galef Kelly Starrett Kevin Kelly Kevin Rose Kim Scott Kumar Thangudu Leonard Shlain Malcolm Gladwell Marc Andreessen Maria Konnikova Maria Popova Matt Ridley Michael Hiltzik Michael Sandel Naval Ravikant Neil Strauss Neil Turok Nick Bostrom Nick Szabo Noah Kagan Noam Chomsky Oliver Sacks P.D. Mangan Paul Bloom Paul Graham Peter Attia Peter Diamandis Peter Thiel Reid Hoffman Rhonda Patrick Richard Feynman Richard Rorty Robert Caro Robert Cialdini Robert Greene Robert Kurzban Robert Langer Robert McNamara Robert Putnam Robert Sapolsky Rory Sutherland Ryan Holiday Sam Altman Sam Harris Scott Adams Scott Belsky Scott Galloway Seth Godin Shawn Baker Shinzen Young Siddhartha Mukherjee Simon Sinek Slavoj Zizek Stephen Wolfram Steve Jobs Steven Pinker Stewart Butterfield Ted Nelson Tiago Forte Tim Ferriss Tim Urban Timothy Gowers Timothy Pychyl Tyler Cowen Vaclav Smil Valter Longo Venkatesh Rao Vinay Gupta Vincent Dignan Will MacAskill Wim Hof Yanis Varoufakis Yuval Harari
Aubrey de Grey: On Breakthroughs in Longevity Extension
26 minutes
Dr. Aubrey de Grey is a biomedical gerontologist based Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation. In this talk Aubrey De Grey details his thoughts on cryo-preservation as well as a synopsis of his thoughts on aging and how he sees technology shaping the aging process going forward. The first seven minutes are focused on cryo-preservation and he delves into the aging process after that.
Arthur De Vany: On Renewing Cycles and Tactics for a Longer Life
68 minutes
The human species is a young species, no more than 200,000 years old; we are also the first species to live long enough to experience aging and significant brain degeneration. The large human brain coevolved with extended human longevity within the last 100,000 years in the harsh world of the Ice Age when intelligence became the basis for survival. Longevity was a requirement to develop a larger brain. The prolonged and complex development required to build the fetal brain left residual stem cells in protected niches in every cell as a reserve for future growth and renewal. What an elegant design — our body is manufactured to have all the spare parts we will ever need in the stem cells hidden in protected niches that can renew or repair damaged parts. Dr. De Vany was one of the first proponents of what has now become the “paleo” diet. He has lived half of his almost 80 years of life in the paleo way. He published his models and methods of an evolutionary lifestyle in his book, The New Evolution Diet, and is now working on a book on aging tentatively titled Renewing Cycles: Healing the wounds of aging through improved cellular defense and systemic renewal signaling.
Aubrey de Grey: On A Post-Aging Planet
94 minutes
Dr. De Grey is known for his view that medical technology may enable human beings alive today to live to lifespans far in excess of any existing authenticated cases. De Grey's research focuses on whether regenerative medicine can thwart the aging process. This video is an introduction to his views on aging and what the world would look like after we have arrested the aging process. He works on the development of what he calls "Strategies for Engineered Negligible Senescence" (SENS), a collection of proposed techniques to rejuvenate the human body and stop aging. To this end, he has identified seven types of molecular and cellular damage caused by essential metabolic processes. SENS is a proposed panel of therapies designed to repair this damage.
Rhonda Patrick: On sulphoraphane, antidepressants, heat/cold exposure and more at Joe Rogan Experience #901
176 minutes
Rhonda discusses sulphoraphane, antidepressants, effects of heat/cold exposure and much more in this extended discussion with Joe.
Rhonda Patrick: On anti-aging, nutrition, cancer, fasting and sauna
65 minutes
Dr. Rhonda Patrick is one of the world's top experts in health and nutrition. Learn more about anti-aging, nutrition, health benefits of heat alteration such as sauna and thesecret ingredients Dr. Rhonda Patrick throws in her breakfast every morning. Also tips for pregnant mothers in terms of nutrition.
Aubrey de Grey: On Aging with Dr. Rhonda Patrick
44 minutes
In this episode of Rhonda's FoundmyFitness show, Rhonda and Aubrey discuss the types of damage that cause aging, how aging results in a decrease in the capacity to repair damage, what role epigenetics play in aging, how people age at different rates, chronic inflammation as a driver of aging, factors that are in young blood that repair damage, the role of nutrition in aging, and recent technologies such as CRISPR, induced pluripotent stem cells that will advance anti-aging research and more.
Valter Longo: On Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
78 minutes
Dr. Rhonda Patrick speaks with Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California. Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases. <br> In this conversation, Rhonda and Valter discuss... <br>The effects of prolonged fasting, which refers to 2-3 day fasting intervals in mice and 4-5 days in humans. <br> Dr. Longo’s work on the fasting-mimicking diet, which is 5 day restricted diet that is meant to simulate some of the biological effects of prolonged fasting while still allowing some food. <br> How clinical trials have demonstrated efficacy for this diet for type 2 diabetes, multiple sclerosis, and cancer patients. <br> Fasting as an inducer of differential stress resistance, where it can simultaneously make cancer cells more sensitive to death while also making healthy cells more resistant to these same death stimuli (such as chemotherapy) which might otherwise induce cell death amongst healthy cells as collateral damage. <br> Fasting as a biological state which humans historically experienced with extreme regularity and we may ultimately need in order to mitigate various disease states. <br> The effects of prolonged fasting on the immune system, namely, how it clears away damaged white blood cells via autophagy and how this causes hematopoietic stem cells to self renew and make more stem cells and also produce new blood cells to fully replenish the white blood cell population. <br> How prolonged fasting causes a shift in the immune cell population towards one that is more representative of youth by normalizing the ratio of myeloid cells to lymphoid cells. <br> The positive effects of prolonged fasting and the fasting-mimicking diet on markers of systemic inflammation, blood glucose levels and other aging biomarkers. <br> The conclusions of Dr. Longo & Dr. Marcus Bock’s research comparing 1 week of the fasting-mimicking diet followed by 6 months of mediterranean diet to six months of a ketogenic diet in people with multiple sclerosis. <br> The strange, somewhat paradoxical role of autophagy genes in cancer progression and some of the open questions surrounding the exact role that these genes are playing. <br> Dr. Longo’s high level thoughts on metformin as an anti-aging drug. <br> How the growth hormone/IGF-1 axis is one of the most important genetic pathways in aging from yeast to worms to mice to humans.